Revisiting sensitivity of senescent cells to BH3 mimetics - CRCL-Sénescence, cancer et vieillissement
Article Dans Une Revue Trends in Pharmacological Sciences Année : 2024

Revisiting sensitivity of senescent cells to BH3 mimetics

Résumé

B cell leukemia/lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics were reported to selectively kill senescent cells and improve age-related diseases. Defining why these cells show increased sensitivity to these molecules will help to identify new pharmacological compounds with senolytic activity. Here, we discuss how recent research findings provide new clues to understand this vulnerability.
Fichier principal
Vignette du fichier
MartinTiPSaccepted.pdf (685.99 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04631483 , version 1 (03-07-2024)

Identifiants

Citer

Nadine Martin, Anda Huna, Athanasios Tsalikis, David Bernard. Revisiting sensitivity of senescent cells to BH3 mimetics. Trends in Pharmacological Sciences, 2024, 45 (4), pp.287-289. ⟨10.1016/j.tips.2024.01.002⟩. ⟨hal-04631483⟩
45 Consultations
3 Téléchargements

Altmetric

Partager

More